Tallahassee and Wichita continue to look around and come upon a very much alive Bill Murray. Aghast that Little Rock has no idea who Bill Murray is, Columbus takes her to Murray's private screening room to watch Ghostbusters, and also to inquire if Wichita has a boyfriend. When they arrive in Hollywood, they dodge zombies and use a map of stars' homes to find Bill Murray ( Bill Murray)'s residence. As he is about to leave, he decides against it and stays. Columbus then says he needs to go his own way, in hopes of finding his family. Wichita confides to Columbus that she knows the rumor is bogus but she will do anything for Little Rock. Wichita and Little Rock hope to make it to an amusement park near Los Angeles that is rumored to be zombie-free. After a standoff, they agree to travel together. He gives a signal for Columbus to drive down and pick him up, and as he gets in, the girls pop out from the backseat. He goes to the Escalade and finds that it is empty. Tallahassee goes to investigate and tells Columbus to stay down the road in case of trouble. They eventually find the Escalade broken down. They drive west because Tallahassee wants to get revenge on Wichita and Little Rock. Columbus and Tallahassee find a Hummer with a duffel bag full of guns. Wichita and Little Rock have been on their own since before the zombie holocaust, using Wichita's good looks to swindle money so they could travel to Los Angeles. Little Rock is fine, and she drives away with Wichita. Columbus gives Wichita his shotgun, which she then uses to rob Tallahassee and Columbus of their remaining weapons and the Escalade.

Little Rock has been bitten and asks them to kill her. When they stop at a grocery store in hopes of finding Tallahassee's coveted Twinkies, they fight off three zombies then find two teenage girls, Wichita ( Emma Stone) and her younger sister, Little Rock ( Abigail Breslin) in the store room. After a tense stand off, Tallahassee agrees to give Columbus a ride as far as Texarkana. He is trying to get to Florida and kill as many zombies as he can on the way, and he is also on a quest to find a Twinkie.

While walking down the highway, he encounters Tallahassee ( Woody Harrelson), driving a huge Cadillac Escalade with a large number 3 painted on the side. In fact, zombies are not his greatest fear: clowns are. Columbus has long been an outsider and somewhat phobic, which he uses to his advantage in avoiding zombies. Only a handful of humans remain, including Columbus ( Jesse Eisenberg), a student at the University of Texas trying to make his way to his home town of Columbus, OH, where he hopes his parents are still alive.

Earth's population has been decimated by a virus, related to the mad cow disease, that turns everyone into flesh-craving zombies.The synopsis below may give away important plot points.

Zombieland movie plot